Studies on the Stereoselective Synthesis of the Marine Antitumor Agent Eleutherobin
โ Scribed by Rich Carter; Kevin Hodgetts; Jeff McKenna; Philip Magnus; Stephen Wren
- Book ID
- 108370827
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 270 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
An asymmetric synthesis of the C3-C13 segment of rhizoxin is described in which the relative stereochemistry of C7 and C8 is established through a chelation-controlled allylation followed by Mitsunobu inversion, and the pyran ring is constructed by a photochemically initiated 6-exo radical cyclizati
Studies on the Total Synthesis of the Macrolide Antitumor Agent Rhizoxin. 2. Synthesis of the C14-C26 Segment.
A stereocontrolled synthesis of the title compound is described. Key steps are an allylsilane addition to a chiral acetal as the major coupling step and a Yamaguchi macrolactonization for ring closure.