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Studies on the Selection of New Matrices for Ultraviolet Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry

โœ Scribed by Joern Krause; Markus Stoeckli; Urs Peter Schlunegger

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
666 KB
Volume
10
Category
Article
ISSN
0951-4198

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โœฆ Synopsis

A new group of compounds has been successfully tested as matrices for ultraviolet matrix-assisted laser desorption/ionization mass spectrometry (UV-MALDI MS). Several new matrices for UV-MALDI MS have been found by choosing, as potential matrices, compounds that perform an intramolecular proton transfer along an intramolecular H-bond under UV irradiation. Compounds of this type are, for example, salicylamide, salicylanilide, several ortho-hydroxyacetophenones and ortho-hydroxybenzophenones. The matrix activity of these compounds is compared to the corresponding meta-and para-isomers and to the matrix activity of such well known matrices as 2,5-dihydroxybenzoic acid and 2,4,6-trihydroxyacetophenone. It was found that meta-and para-substituted hydroxycarbonyl compounds show either a significantly lower or no matrix activity compared with the ortho isomers.

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