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Studies on the metabolism and toxicological detection of the designer drug 2,5-dimethoxy-4-methyl-β- phenethylamine (2C-D) in rat urine using gas chromatographic/mass spectrometric techniques

✍ Scribed by Denis S. Theobald; Hans H. Maurer

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
376 KB
Volume
41
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

The phenethylamine‐derived designer drug 2,5‐dimethoxy‐4‐methyl‐β‐phenethylamine (2C‐D) was found to be metabolized in rats by O‐demethylation at position 2 or 5 followed by N‐acetylation or by deamination with oxidation to the corresponding acids or reduction to the corresponding alcohol. Furthermore, 2C‐D was hydroxylated at the methyl group or deaminated followed by reduction to the corresponding alcohol or by oxidation to the corresponding acid. Most of the metabolites were excreted in conjugated form. The authors' systematic toxicological analysis (STA) procedure using full‐scan GC/MS allowed the detection of an intake of a dose of 2C‐D in rat urine that corresponds to a common drug user's dose. Assuming similar metabolism, the described STA procedure should be suitable for proof of an intake of 2C‐D in human urine. Copyright © 2006 John Wiley & Sons, Ltd.

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