New designer drug, 2,5-dimethoxy-4-propylthio-β-phenethylamine (2C-T-7): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry

✍ Scribed by Denis S. Theobald; Susanna Fehn; Hans H. Maurer

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 234 KB
• Volume: 40
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/jms.784

✦ Synopsis

Abstract

Studies are described on the metabolism and toxicological analysis of the phenethylamine‐derived designer drug 2,5‐dimethoxy‐4‐propylthio‐β‐phenethylamine (2C‐T‐7) in rat urine using gas chromatography/mass spectrometry (GC/MS). The identified metabolites indicated that 2C‐T‐7 was metabolized by hydroxylation of the propyl side chain followed by N‐acetylation and sulfoxidation and also by deamination followed by oxidation to the corresponding acid or by reduction to the corresponding alcohol. To a minor extent, 2C‐T‐7 was also metabolized by S‐dealkylation followed by N‐acetylation, S‐methylation and sulfoxidation. The authors' systematic toxicological analysis (STA) procedure using full‐scan GC/MS after acid hydrolysis, liquid–liquid extraction microwave‐assisted acetylation allowed the detection of an intake of a dose of 2C‐T‐7 in rat urine that corresponds to a common drug users' dose. Assuming similar metabolism, the described STA procedure should be suitable for proof of an intake of 2C‐T‐7 in human urine. Copyright © 2005 John Wiley & Sons, Ltd.