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Designer drug 2,4,5-trimethoxyamphetamine (TMA-2): Studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques

✍ Scribed by Andreas H. Ewald; Giselher Fritschi; Hans H. Maurer

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
249 KB
Volume
41
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

Studies are described on the metabolism and the toxicological detection of the amphetamine‐derived designer drug 2,4,5‐trimethoxyamphetamine (TMA‐2) in rat urine using gas chromatographic/mass spectrometric (GC/MS) techniques. The identified metabolites indicated that TMA‐2 was metabolized by oxidative deamination to the corresponding ketone followed by reduction to the corresponding alcohol, O‐demethylation followed by oxidative deamination, and finally O,O‐bis‐demethylation. All metabolites carrying hydroxy groups were found to be partly excreted in urine as glucuronides and/or sulfates. The authors' systematic toxicological analysis (STA) procedure using full‐scan GC/MS after acid hydrolysis, liquid‐liquid extraction, and microwave‐assisted acetylation allowed the detection, in rat urine, of an intake of TMA‐2 that corresponds to a common drug users' dose. Assuming similar metabolism, the described STA procedure in human urine should be suitable as proof of an intake of TMA‐2. Copyright © 2006 John Wiley & Sons, Ltd.

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