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Studies on the mechanism of inhibition of nuclear triiodothyronine binding by fatty acids

โœ Scribed by F.R.M. van der Klis; W.M. Wiersinga; J.J.M. de Vijlder


Book ID
118323595
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
282 KB
Volume
246
Category
Article
ISSN
0014-5793

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Inhibition of nuclear T3 binding by fatt
โœ Wilmar M. Wiersinga; Inder J. Chopra; Guadalupe N. Chua Teco ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 945 KB

Studies were performed to evaluate a possible modulatory role of lipids on the binding of T, to rat liver nuclear receptors in vitro. Unsaturated fatty acids were potent inhibitors of the binding of ['261] T, to isolated rat liver nuclei. Doses (in pmol/L) causing a 50% inhibition of nuclear T, bind