Effect of midbrain raphe lesion on the a
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R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli
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Article
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1973
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Springer
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English
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The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine