Four fluoro-olefin analogs of CGP 49823 have been synthesized. Comparison of their binding afthaities for the NKI receptor suggests an active contbrmation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent.
โฆ LIBER โฆ
Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs.
โ Scribed by Siem J. Veenstra; Kathleen Hauser; Claudia Betschart
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 208 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0960-894X
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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