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Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs.

โœ Scribed by Siem J. Veenstra; Kathleen Hauser; Claudia Betschart


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
208 KB
Volume
7
Category
Article
ISSN
0960-894X

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Four fluoro-olefin analogs of CGP 49823 have been synthesized. Comparison of their binding afthaities for the NKI receptor suggests an active contbrmation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent.

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