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Studies on the active conformation of the NK1 antagonist CGP 49823. Part 21. Fluoro-olefin analogs of tertiary amide rotamers.

✍ Scribed by Siem J. Veenstra; Kathleen Hauser; Peter Felber

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 226 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00624-5

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✦ Synopsis

Four fluoro-olefin analogs of CGP 49823 have been synthesized. Comparison of their binding afthaities for the NKI receptor suggests an active contbrmation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent.

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✍ Siem J. Veenstra; Kathleen Hauser; Claudia Betschart 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 208 KB