SAR of 2-benzyl-4-aminopiperidines NK1 antagonists. Part 21. synthesis of CGP 49823
โ Scribed by Siem J. Veenstra; Kathleen Hauser; Walter Schilling; Claudia Betschart; Silvio Ofner
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 316 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Four fluoro-olefin analogs of CGP 49823 have been synthesized. Comparison of their binding afthaities for the NKI receptor suggests an active contbrmation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent.
Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. Part 3. Synthesis of (ยฑ)-N-[2-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and Evaluation of NK 1 -NK 2 Dual Antagonistic Activities. -In order to obtain more potent NK 1 -NK 2 dual antagonists a