✍ Scribed by Benoǐt Rigo; Claude Laruelle
No coin nor oath required. For personal study only.
The synthesis of new N‐(4‐chlorobenzyl) and N‐(4‐chlorobenzoyl)pyroglutamic esters and amids whose the structure conserves the main structural features of the cholesterol lowering agent crilvastatin is described.
📜 SIMILAR VOLUMES
## Abstract The synthesis of esters, amides, pyrrolidinone and succinimide analogs of a new inhibitor of tubulin polymerization, methyl __N__‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) was studied.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Abstract Some ways to use the __N__‐acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl __N__‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3‐(3,4,5‐trimethoxyph