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Studies on pyrrolidinones: Some attempts to improve the anticancer properties of methyl n-(3,4,4′,5-tetramethoxybenzhydryl)pyroglutamate (HEI 81)

✍ Scribed by Anne Bourry; Benoît Rigo; Géarard Sanz; Daniel Couturier

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
92 KB
Volume
39
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The synthesis of esters, amides, pyrrolidinone and succinimide analogs of a new inhibitor of tubulin polymerization, methyl N‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) was studied.

📜 SIMILAR VOLUMES

ChemInform Abstract: Studies on Pyrrolid
ChemInform Abstract: Studies on Pyrrolidinones: Some Attempts to Improve the Anticancer Properties of Methyl N-(3,4,4′,5-Tetramethoxybenzhydryl)pyroglutamate (HEI 81).
✍ Anne Bourry; Benoit Rigo; Gerard Sanz; Daniel Couturier 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Studies on pyrrolidinones: Some attempts
Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl n-(3,4,4′,5-tetramethoxybenzhydryl)pyroglutamate (hei 81) by using n-acyl iminium salts methodologies
✍ Anne Bourry; Franck Pitard; Benoît Rigo; Géarard Sanz; Fabrice Camus; Bernadette 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 166 KB

## Abstract Some ways to use the __N__‐acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl __N__‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3‐(3,4,5‐trimethoxyph