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Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl n-(3,4,4′,5-tetramethoxybenzhydryl)pyroglutamate (hei 81) by using n-acyl iminium salts methodologies

✍ Scribed by Anne Bourry; Franck Pitard; Benoît Rigo; Géarard Sanz; Fabrice Camus; Bernadette Norberg; Françlois Durant; Daniel Couturier

Publisher: Journal of Heterocyclic Chemistry
Year: 2002
Tongue: English
Weight: 166 KB
Volume: 39
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570390116

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✦ Synopsis

Abstract

Some ways to use the N‐acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3‐(3,4,5‐trimethoxyphenyl)dihydropy‐rrolo[1,2‐c]oxazole‐1,5‐dione).

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