## Abstract Dimethyl 7‐methoxycarbonylmethyl‐5‐oxo‐1,2,3,5‐tetrahydro‐indolizine‐3,8‐dicarboxylate was synthesized starting from methyl pyroglutamate. A study was made of the reactions of this highly functionalized pyridone with ethyl iodide, selenium oxide, isoamyl nitrite and formaldehyde. Litera
Studies on Pyrrolidinones. Synthesis of New α-Pyridones Derivatives.
✍ Scribed by Natacha Malecki; Raymond Houssin; Jean-Pierre Henichart; Daniel Couturier; Ferdinand Petra; Laurent Legentil; Benoit Rigo
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 165 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Catalyzed __N__‐alkylation of __N,O__‐bistrimethylsilyl pyroglutamic acid with trimethylsilyl benzhydryl ethers yields trimethylsilyl __N__‐benzhydrylpyroglutamates. Hydrolysis of these compounds or saponification of the methyl esters gives the corresponding acids.
## Abstract The synthesis of new __N__‐(4‐chlorobenzyl) and __N__‐(4‐chlorobenzoyl)pyroglutamic esters and amids whose the structure conserves the main structural features of the cholesterol lowering agent crilvastatin is described.