Studies on pyrrolidinones. Synthesis of methyl N-(4-nitrobenzyl)pyroglutamate
✍ Scribed by Benoǐt Rigo; Daniel Couturier
- Book ID
- 112127764
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1985
- Tongue
- English
- Weight
- 78 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
## Abstract Pyroglutamic acid was transformed into 1‐[(__N__‐Acetylarylamino)methyl]pyroglutamic acid derivatives by using trimethylsilyl variations of the Mannich reaction.
## Abstract Condensation of trimethoxyphenyl naphthylcarbinol trimethylsilyl ether with methyl __N__‐trimethylsilyl‐pyroglutamate yields two separable esters. The Friedel‐Crafts cyclization of the acids obtained after saponification gives analogs of azapodophylloxin. Reduction and treatment of the
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