The site specificities for intercalation of steffimycin B, adriamycin, echinomycin, and ethidium bromide with DNA have been determined by CD first-neighbor analysis. The first three, which are antineoplastic antibiotics, all exhibit preferential binding to sites comprised of guanine and cytosine (Gp
โฆ LIBER โฆ
Studies on binding of toromycin, an antitumor antibiotic, to DNA
โ Scribed by Kazuo Shishido; Ken-ichi Joho; Masakazu Uramoto; Kiyoshi Isono; Tikam Jain
- Book ID
- 115759461
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 731 KB
- Volume
- 136
- Category
- Article
- ISSN
- 0006-291X
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These studies have been conducted as a first step toward investigating the molecular mechanism by which DNA-dependent RNA polymerase recognizes a specific region of DNA. The DNA moieties are either bound to or freed from RNA polymerase. Results obtained so far indicate that the DNA moieties remainin