The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit
✦ LIBER ✦
Influence of local excitations in DNA conformation on binding of nonintercalating antitumor antibiotic in the minor groove
✍ Scribed by V. Kothekar; Mrigank; A. K. Royyuru; A. Kalia
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 397 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0020-7608
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## Abstract Antiparallel polyamides containing 1__H__‐pyrrole, 1__H__‐imidazole, and 3‐hydroxy‐1__H__‐pyrrole amino acids display a preference for minor‐groove binding oriented NC with respect to the 5′‐3′ direction of the DNA helix. We find that replacement of a central Py/Py pair with a __β__/__