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Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé

✍ Scribed by W. Kostowski; E. Giacalone; S. Garattini; L. Valzelli

Book ID
118319999
Publisher
Elsevier Science
Year
1968
Tongue
English
Weight
391 KB
Volume
4
Category
Article
ISSN
0014-2999

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✍ R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli 📂 Article 📅 1973 🏛 Springer 🌐 English ⚖ 267 KB

The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine