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Studies on bcl-2 protein in cultured lymphoid cells.

✍ Scribed by Agata Filip; Danuta Rożynkowa

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
525 KB
Volume
18
Category
Article
ISSN
1065-6995

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✦ Synopsis

ABSTRACT

Bc1‐2 protein was analysed in cell cultures derived from non‐Hodgkin lymphomas and chronic lymphocytic leukaemia patients. The presence of bc1‐2 proto‐oncogene protein product has been demonstrated on cytospin preparations utilising immunochemical methods. The correlation between the expression of the bc1‐2 protein and the appearance of proliferation‐ or differentiation related figures was studied. The reported bc1‐2 up regulation in malignant lymphoid cells was confirmed in haemo‐ and lymphopoietic progenitor cells as well as in TPA/PHA activated peripheral blood lymphocytes. In comparison to neoplastic cells lower intensity of bc1‐2 positive staining in freshly isolated cells from non‐leukaemic tissue was observed.

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