The interaction of a nonsteroidal anti-inflammatory drug, naproxen, with \(\beta\)-CD has been studied by several analytical techniques, including 1-D and 2-D proton NMR, fluorescence spectroscopy, and FAB-MS. The negative ion FAB-MS confirmed the existence of a 1:1 inclusion complex of naproxen and
Studies on a novel modified β-cyclodextrin inclusion complex
✍ Scribed by Lixiu Ding; Jiang He; Lizhen Huang; Ruihua Lu
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 713 KB
- Volume
- 979
- Category
- Article
- ISSN
- 0022-2860
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## Abstract An inclusion complex of fenbufen with β‐cyclodextrin (β‐CD) in aqueous solution was characterized by ^1^H‐NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (__M__^−1^) was calculated. The geometry of the inclusion complex was established