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Studies on a naturally occurring human antibody active against mouse landschutz ascites tumor cells III. The nature of the antigenic site on the tumor cell

✍ Scribed by R. Laskov; E. Simon; J. Gross

Publisher: John Wiley and Sons
Year: 1968
Tongue: French
Weight: 829 KB
Volume: 3
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910030412

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✦ Synopsis

Each value in the

Table is the arithmetic mean of the values obtained in two similar experiments.

The amount of antibody activity present in the unabsorbed serum was taken as 100:1,.

The ratio between the specific activities (in LD,, unitsjmg) of the eluate and the unabsorbed serum.

📜 SIMILAR VOLUMES

Studies on a naturally occurring human a

Studies on a naturally occurring human antibody active against mouse landschutz ascites tumor cells: II. Identification of the antibody as igm and its partial purification

✍ R. Laskov; E. Simon; D. Ram; J. Gross 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 French ⚖ 583 KB

## The cytotoxic antibody in normal human serum, active against mouse tumor cells, was identified as a 19s macroglobulin by means of Sephadex gel filtration, DEAEcellirlose chromatography and density-gradient centrifugation procedures. A purified IgM fraction was isolated ji-om normal human serum.

Studies on a naturally occurring human a

Studies on a naturally occurring human antibody active against mouse landschutz ascites tumor cells: I. Cytotoxicity assay system and quantitation in normal sera

✍ R. Laskov; E. Simon; J. Gross 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 French ⚖ 700 KB

A quantitative cytolytic assay system was developed for the titration of the natural cytotoxin of human serum ( N H S j which is active against Landschutz ascites tumor cells. The assay system consists of NHS,, or N H S as a source of antibody and human umbilical cord serum as a source of complement

Anti-tumor activity in human serum: Anti

Anti-tumor activity in human serum: Antibodies detecting blood-group-A-like antigen on the surface of tumor cells in culture

✍ Dr. Eda T. Bloom; John L. Fahey; Inga A. Peterson; Gayla Geering; Michael Bernha 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 740 KB

## Abstract Sera from many patients with tumors showed demonstrable cytotoxic antibody activity against selected human tumor cells in culture. The antibody activity detected in the present study was not found to be specific for tumors, but was shown to be directed against an antigen that is serolog