Studies of myelin proteins in multiple sclerosis brain tissue
β Scribed by John L. Trotter; Cindy L. Wegescheide; William F. Garvey; Wallace W. Tourtellotte
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 277 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0364-3190
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Myelin was isolated from histologically normal white matter and plaques from MS patients and from white matter of neurologically normal controls. No difference was found in the total lipid content. There were no detectable deficits in MS myelin of phosphoglycerides, plasmalogens or sphingolipids. Ga
Myelin basic protein (MBP) occurs as a number of charge isomers due to phosphorylation, deamidation, and deimination of arginine to citrulline. All of these modifications decrease the net positive charge of the protein and its ability to cause aggregation of negatively charged lipid vesicles. This i