𝔖 Bobbio Scriptorium
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Myelin basic protein binding cells in active multiple sclerosis

✍ Scribed by Dr. Arthur A. Vandenbark; Jules V. Hallum; Roy L. Swank; Alex Tong; Denis R. Burger


Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
524 KB
Volume
6
Category
Article
ISSN
0364-5134

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T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence

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Previous studies from our laboratory showed the development of circulating T lymphocytes sensitized to myelin basic protein (MBP) in guinea pigs challenged with MBP. Also, lymphocytes sensitized to MBP were found in patients with multiple sclerosis (MS). In this report, we describe the kinetics of M