Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis
✍ Scribed by Dr. Pierre J. Talbot; Jean-Sébastien Paquette; Cristina Ciurli; Jack P. Antel; France Ouellet
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 852 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0364-5134
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Several reports have suggested an association of human herpesvirus 6 (HHV-6) with multiple sclerosis. Autoreactive T lymphocytes directed against myelin components seem to contribute to the pathogenesis of the disease. It has been suggested that molecular mimicry between viral and self-antigens migh
T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence