A possible role for altered myelin basic protein in multiple sclerosis
β Scribed by John N. Whitaker; Galen W. Mitchell
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 215 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0364-5134
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π SIMILAR VOLUMES
The common marmoset Callithrix jacchus (C. jacchus) is an outbred species characterized by a naturally occurring bone marrow chimerism and susceptibility to a form of experimental autoimmune encephalomyelitis (EAE) resembling multiple sclerosis (MS). T cell clones specific for the myelin antigen, my
Myelin basic protein (MBP) occurs as a number of charge isomers due to phosphorylation, deamidation, and deimination of arginine to citrulline. All of these modifications decrease the net positive charge of the protein and its ability to cause aggregation of negatively charged lipid vesicles. This i