Studies in mass spetrometry sporidesmin and sporidesmin B
β Scribed by J.S. Shannon
- Book ID
- 104241912
- Publisher
- Elsevier Science
- Year
- 1963
- Tongue
- French
- Weight
- 253 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Sporidesmin, the mycotoxin responsible for 'facial eczema' in ruminants, has previously been shown to generate superoxide radical and hydrogen peroxide. In the present study, the formation of the third 'active oxygen' species, hydroxyl radical, has been demonstrated. This species is produced both du
Formation of hydrogen peroxide, the dismutation product of superoxide radical, has been demonstrated in erythrocytes incubated with the mycotoxin sporidesmin. Erythrocytic thiols, both non-protein and protein-bound, were depleted in the presence of sporidesmin, whilst haemoglobin was oxidized to met
## Abstract The mycotoxin sporidesmin has previously been shown to generate superoxide radical. This reaction involves autoxidation of the reduced form of the mycotoxin, a dithiol. In the present study, a number of mercaptideβforming metals have been shown to inhibit superoxide formation from spori