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Metal complexes of sporidesmin D and dimethylgliotoxin, investigated by electrospray ionisation mass spectrometry

✍ Scribed by Jane C Woodcock; William Henderson; Christopher O Miles; Brian K Nicholson


Book ID
108403627
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
220 KB
Volume
84
Category
Article
ISSN
0162-0134

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The noncovalent binding of the antitumour drugs daunomycin and nogalamycin to duplex DNA has been studied using electrospray ionisation mass spectrometry (ESI-MS). The conditions for the preparation of drug/duplex DNA complexes and for their detection by ESI-MS have been optimised. Ions correspondin