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Studies on the mechanism of toxicity of the mycotoxin sporidesmin. IV. Inhibition by copper-chelating agents of the generation of superoxide radical by sporidesmin

✍ Scribed by K. Munday


Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
459 KB
Volume
5
Category
Article
ISSN
0260-437X

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Studies on the mechanism of toxicity of
✍ R. Munday πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 490 KB

## Abstract The mycotoxin sporidesmin has previously been shown to generate superoxide radical. This reaction involves autoxidation of the reduced form of the mycotoxin, a dithiol. In the present study, a number of mercaptide‐forming metals have been shown to inhibit superoxide formation from spori

Studies on the mechanism of toxicity of
✍ R. Munday πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 578 KB

Sporidesmin, the mycotoxin responsible for 'facial eczema' in ruminants, has previously been shown to generate superoxide radical and hydrogen peroxide. In the present study, the formation of the third 'active oxygen' species, hydroxyl radical, has been demonstrated. This species is produced both du

Studies on the mechanism of toxicity of
✍ R. Munday πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 546 KB

Formation of hydrogen peroxide, the dismutation product of superoxide radical, has been demonstrated in erythrocytes incubated with the mycotoxin sporidesmin. Erythrocytic thiols, both non-protein and protein-bound, were depleted in the presence of sporidesmin, whilst haemoglobin was oxidized to met

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✍ Kinsey, V. Everett ;Grant, W. Morton πŸ“‚ Article πŸ“… 1947 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 686 KB

It will be recalled that one of the objectives of this series of studies was to learn more about the mechanism by which mustard gas (H) produces injurious effects on cells. Direct chemical studies have accounted for inhibition of carbohydrate metabolism on tlie basis of reaction with intracellular