๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Studies in macrolide synthesis: A highly stereoselective synthesis of (+)-(9S)-dihydroerythronolide a using macrocyclic stereocontrol

โœ Scribed by Ian Paterson; David J. Rawson


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
361 KB
Volume
30
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Studies in macrolide synthesis: A stereo
โœ Ian Paterson; M.Anne Lister; Roger D. Norcross ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 350 KB

The (9s)-macrolide 1 (P = TBS) was prepared in 14 steps (5% yield) with 63% overall ds starting from the ethyl ketone ($2. The Cl-C7 and Q-C13 segments, 3 and 4, were obtained via boron enolate aldol reactions mediated by (+)-and (-)-(Ipc)zBOTf, respectively. Conventional reduction conditions using

A stereoselective total synthesis of (9S
โœ Hitoshi Tone; Takao Nishi; Yuji Oikawa; Masataka Hikota; Osamu Yonemitsu ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 269 KB

A rather facile stereoselective total synthesis of (9S)-9-dihydroerythronolide A starting from D-glucose was achieved via coupling of Cl-C6 and C7-Cl5 segments and subsequent macrolactonizotion. The well known macrolide antibiotic erythromycin A (1) has been an attractive synthetic target for moder

Studies in macrolide synthesis: Stereoco
โœ Ian Paterson; Malcolm D. McLeod ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 329 KB

The Ct-Ct3 segment 6 of concanamycin A (1) was prepared by a highly stereocontrolled route (87% overall ds) in 16 steps from the ester 9. Key steps are the one-pot aldol/reduction, 8 + 12, and the HWB reaction, 18 + 19 + 6.8 1997 Elsevier Science Ltd.