The (9s)-macrolide 1 (P = TBS) was prepared in 14 steps (5% yield) with 63% overall ds starting from the ethyl ketone ($2. The Cl-C7 and Q-C13 segments, 3 and 4, were obtained via boron enolate aldol reactions mediated by (+)-and (-)-(Ipc)zBOTf, respectively. Conventional reduction conditions using
Studies in macrolide synthesis: A highly stereoselective synthesis of (+)-(9S)-dihydroerythronolide a using macrocyclic stereocontrol
โ Scribed by Ian Paterson; David J. Rawson
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 361 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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