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A stereoselective total synthesis of (9S)-9-dihydroerythronolide A from D-glucose

✍ Scribed by Hitoshi Tone; Takao Nishi; Yuji Oikawa; Masataka Hikota; Osamu Yonemitsu

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 269 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96566-3

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✦ Synopsis

A rather facile stereoselective total synthesis of (9S)-9-dihydroerythronolide A starting from D-glucose was achieved via coupling of Cl-C6 and C7-Cl5 segments and subsequent macrolactonizotion.

The well known macrolide antibiotic erythromycin A (1) has been an attractive synthetic target for modern synthetic chemists, because of its complex chemical structure as well as important biological activity, and many new synthetic methodologies have been developed.2 As ', J)

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