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Structure of the proteasome activator REGα (PA28α)

✍ Scribed by Hill, Christopher P.; Knowlton, J. Randolph; Johnston, Steven C.; Whitby, Frank G.; Realini, Claudio; Zhang, Zhiguo; Rechsteiner, Martin

Book ID
118675123
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
610 KB
Volume
390
Category
Article
ISSN
0028-0836

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Activity of the 20S proteasome, which performs much of the cytosolic and nuclear proteolysis in eukaryotic cells, is controlled by regulatory complexes that bind to one or both ends of the cylindrical proteasome. One of these complexes, the 11S regulator (REG), is a complex of 28 kDa subunits that i