Structure of blasticidin A
β Scribed by Shohei Sakuda; Makoto Ono; Hiroyuki Ikeda; Yasuhito Inagaki; Jiro Nakayama; Akinori Suzuki; Akira Isogai
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 226 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
In previous papers"', we have reported the isolation and characterization of a new nucleoside designated cytosinine from the hydrolysis products of blasticidin.S, a useful antibiotic against rice blast desease. We wish to present the details leading to the assignment of structure I to cytosinine. Cy
reoeived in UIC for publioation 9 My 1972) Detoxin Dl, one of the most active principle of detoxin complex produced by Streotomyces caespitosus var. detoxicus, is a selective antagonist of blasticidin S and shovs several interesting biological activities to counteract the toxicity of the antibiotic
Blasticidin S is an antibiotic produced by Streotomyces -gi\_seochromogene\_s\_' and the structure has been established as shown in FIG. 1: It consists of a pyrimidine nucleoside and P-amino acid named cytosinine and blastidic acid, respectively. Hitherto, several reports had been published on the