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Biogenesis of blasticidin S

✍ Scribed by Haruo Seto; Isamu Yamaguchi; Noboru Ōtake; Hiroshi Yonehara

Publisher
Elsevier Science
Year
1966
Tongue
French
Weight
222 KB
Volume
7
Category
Article
ISSN
0040-4039

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✦ Synopsis

Blasticidin S is an antibiotic produced by Streotomyces -gi_seochromogene_s_' and the structure has been established as shown in FIG. 1: It consists of a pyrimidine nucleoside and P-amino acid named cytosinine and blastidic acid, respectively. Hitherto, several reports had been published on the

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The structure of blasticidin S
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In the works on the chemistry of blasticidln S (I), a methabollte.of Streotomyces griseochromogenes, we have demonstrated its unique structural feature which consists of a new nucleoslde cytosinine (II) ana a new amino acid, blastiaic 1-4 acid (III) on the basis of chemical reactions and spectral ev

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Blasticidin S-resistant mutants of S. cerevisiae were isolated and characterized. Resistant mutations were found to fall into two complementation groups. A single recessive nuclear gene was responsible for each group, donated as blsl and bls2, respectively. A gene blsl was linked to an ilv3 gene loc

Structure of cytosinine, a structural co
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✍ Noboru Ōtake; Setsuo Takeuchi; Toyoshige Endō; Hiroshi Yonehara 📂 Article 📅 1965 🏛 Elsevier Science 🌐 French ⚖ 176 KB

In previous papers"', we have reported the isolation and characterization of a new nucleoside designated cytosinine from the hydrolysis products of blasticidin.S, a useful antibiotic against rice blast desease. We wish to present the details leading to the assignment of structure I to cytosinine. Cy