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Structure of a nucleoside analogue, 3'-deoxy-3'-fluorothymidine

✍ Scribed by Everaert, D. H. ;Peeters, O. M. ;Blaton, N. M. ;De Ranter, C. J.


Book ID
114507296
Publisher
International Union of Crystallography
Year
1990
Tongue
English
Weight
341 KB
Volume
46
Category
Article
ISSN
0108-2701

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A short route to 3β€²-deoxy-3β€²-fluorothymi
✍ Motawia, Mohammed S. ;Pedersen, Erik B. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 336 KB

## Abstract The 5‐OH‐protected methyl glycosides 2 and 3 were epimerized to give the corresponding epimers 6 and 7 via an oxidation‐reduction procedure. Reaction of 6 with diethylamino‐sulfur trifluoride (DAST) afforded the fluoro sugar 8, which was coupled with thymine to give 3′‐deoxy‐3′‐fluoroth