Structure of 5-[(1S,2S)-2-chlorocyclopropyl]-1-(2-deoxy-β-d-ribofuranosyl)uracil
✍ Scribed by Mosimann, S. C. ;Santarsiero, B. D. ;James, M. N. G. ;Tandon, M. ;Wiebe, L. I. ;Knaus, E. E.
- Book ID
- 114507267
- Publisher
- International Union of Crystallography
- Year
- 1990
- Tongue
- English
- Weight
- 356 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0108-2701
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## Abstract The dinucleoside phosphate __Π__~d~p__Π__~d~ (**4**) was synthesized from the monomers 1‐(5′‐__O__‐monomethoxytrityl ‐ 2′ ‐ deoxy ‐ β ‐ D ‐ ribofuranosyl) ‐ 2 (1 __H__) ‐ pyridone ((MeOTr) __Π__~d~, **2**) and 1‐(5′‐__O__‐phosphoryl‐3′‐__O__‐acetyl‐2′‐deoxy‐β‐D‐ribofuranosyl)‐(1__H__)‐p
The synthesis of t h e title canpound (7) is described. [2-14C] cytosine (I) is treated with an aqueous mixture of sodium bisulfite and sodium sulfate at 8OoC for 30 rnin. The resulting solid is then treated with aqueous sodiun hydroxide and passed through a cation exchange colunn, producing [ Z-14C