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Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

✍ Scribed by Stefan Steinbacher; Johannes Kaiser; Juraithip Wungsintaweekul; Stefan Hecht; Wolfgang Eisenreich; Stefan Gerhardt; Adelbert Bacher; Felix Rohdich


Book ID
115631629
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
713 KB
Volume
316
Category
Article
ISSN
0022-2836

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Chemical Synthesis of Enantiopure 2-C-Me
✍ Jean-FranΓ§ois Hoeffler; C Pale-Grosdemange; Michel Rohmer πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 117 KB

Optically pure 2-C-methyl-d-erythritol 4-phosphate, a key intermediate in the mevalonate-independent route for isoprenoid biosynthesis, is conveniently synthesized from 1,2-O-isopropylidene-a-d-xylofuranose, including the possibility of radiolabeling of this substrate.