✦ LIBER ✦

Structure-Based Design, Synthesis, and Biological Evaluation of Indomethacin Derivatives as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors §

✍ Scribed by Wey, Shiow-Jyi; Augustyniak, Michael E.; Cochran, Edward D.; Ellis, James L.; Fang, Xinqin; Garvey, David S.; Janero, David R.; Letts, L. Gordon; Martino, Allison M.; Melim, Terry L.; Murty, Madhavi G.; Richardson, Steward K.; Schroeder, Joseph D.; Selig, William M.; Trocha, A. Mark; Wexler, Roseanne S.; Young, Delano V.; Zemtseva, Irina S.; Zifcak, Brian M.

Book ID: 120008962
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 270 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0611861

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of 1,5-Diaryl-1,2,4-triazole Derivatives as Selective Cyclooxygenase-2 Inhibitors

✍ Bo Jiang; Yi Zeng; Meng-Jie Li; Jin-Yi Xu; Yong-Na Zhang; Qiu-Juan Wang; Ni-Yue 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB 👁 2 views

Design, Synthesis and Biological Evaluat

Design, Synthesis and Biological Evaluation of 2-(2-Aryl-morpholino-4-yl)ethyl Esters of Indomethacin as Potential Cyclooxygenase-2 (COX-2) Inhibitors

✍ Lei Shi; Aixi Hu; Jiangping Xu; Yiping Jiang 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

Second-Generation Aspirin and Indomethac

Second-Generation Aspirin and Indomethacin Prodrugs Possessing an O 2 -(Acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate Nitric Oxide Donor Moiety: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies

✍ Velázquez, Carlos A.; Chen, Qiao-Hong; Citro, Michael L.; Keefer, Larry K.; Knau 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 173 KB

Rofecoxib Analogues Possessing a Nitric

Rofecoxib Analogues Possessing a Nitric Oxide Donor Sulfohydroxamic Acid (SO2NHOH) Cyclooxygenase-2 Pharmacophore: Synthesis, Molecular Modeling, and Biological Evaluation as Anti-inflammatory Agents

✍ Dr. Atul Bhardwaj; Dr. Zhangjian Huang; Dr. Jatinder Kaur; Prof. Edward E. Knaus 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 715 KB

ChemInform Abstract: Design, Synthesis,

ChemInform Abstract: Design, Synthesis, and Biological Evaluation of 1,5-Diaryl-1,2,4-triazole Derivatives as Selective Cyclooxygenase-2 Inhibitors.

✍ Bo Jiang; Yi Zeng; Meng-Jie Li; Jin-Yi Xu; Yong-Na Zhang; Qiu-Juan Wang; Ni-Yue 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 2 views

## Abstract The results of biological tests show that compound (I) is a potent and selective inhibitor of COX‐2 (IC~50~ = 0.37 μM) being equipotent to celecoxib.

Synthesis and biological evaluation of f

Synthesis and biological evaluation of furoxan-based nitric oxide-releasing derivatives of glycyrrhetinic acid as anti-hepatocellular carcinoma agents

✍ Yisheng Lai; Lihong Shen; Zhenzhen Zhang; Wenqing Liu; Yihua Zhang; Hui Ji; Jide 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 463 KB

A series of novel furoxan-based nitric oxide (NO)-releasing derivatives of glycyrrhetinic acid (GA) were designed, synthesized, and evaluated for their in vitro cytotoxicity against human hepatocellular carcinoma (HCC) and non-tumor liver cells. Five furoxan/GA hybrids, 7b-d, 7f, and 7g, displayed p