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Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2- a ]benzimidazol-5(6 H )-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity

✍ Scribed by Martin, Matthew W.; Newcomb, John; Nunes, Joseph J.; Boucher, Christina; Chai, Lilly; Epstein, Linda F.; Faust, Theodore; Flores, Sylvia; Gallant, Paul; Gore, Anu; Gu, Yan; Hsieh, Faye; Huang, Xin; Kim, Joseph L.; Middleton, Scot; Morgenstern, Kurt; Oliveira-dos-Santos, Antonio; Patel, Vinod F.; Powers, David; Rose, Paul; Tudor, Yanyan; Turci, Susan M.; Welcher, Andrew A.; Zack, Debra; Zhao, Huilin; Zhu, Li; Zhu, Xiaotian; Ghiron, Chiara; Ermann, Monika; Johnston, David; Saluste, Carl-Gustaf Pierre

Book ID: 118146132
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 373 KB
Volume: 51
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm701095m

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