Imidazoquinoxaline Src-Family Kinase p56 Lck Inhibitors: SAR, QSAR, and the Discovery of ( S )- N -(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5- a ]pyrido[3,2- e ]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity

✍ Scribed by Chen, Ping; Doweyko, Arthur M.; Norris, Derek; Gu, Henry H.; Spergel, Steven H.; Das, Jagabundhu; Moquin, Robert V.; Lin, James; Wityak, John; Iwanowicz, Edwin J.; McIntyre, Kim W.; Shuster, David J.; Behnia, Kamelia; Chong, Saeho; de Fex, Henry; Pang, Suhong; Pitt, Sydney; Shen, Ding Ren; Thrall, Sara; Stanley, Paul; Kocy, Octavian R.; Witmer, Mark R.; Kanner, Steven B.; Schieven, Gary L.; Barrish, Joel C.

• Book ID: 126430521
• Publisher: American Chemical Society
• Year: 2004
• Tongue: English
• Weight: 370 KB
• Volume: 47
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm030217e