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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones

โœ Scribed by Skulnick, Harvey I.; Johnson, Paul D.; Aristoff, Paul A.; Morris, Jeanette K.; Lovasz, Kristine D.; Howe, W. Jeffrey; Watenpaugh, Keith D.; Janakiraman, Musiri N.; Anderson, David J.; Reischer, Robert J.


Book ID
111696133
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
527 KB
Volume
40
Category
Article
ISSN
0022-2623

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โœ Vincent J. Kalish; John H. Tatlock; Jay F. Davies II; Stephen W. Kaldor; Bruce A ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 290 KB

The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor