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Structure-Based Design and Synthesis of Substituted 2-Butanols as Nonpeptidic Inhibitors of HIV Protease: Secondary Amide Series

โœ Scribed by Reich, Siegfried H.; Melnick, Michael; Pino, Mark J.; Fuhry, Mary Ann M.; Trippe, Anthony J.; Appelt, Krzysztof; Davies, Jay F.; Wu, Bor-Wen; Musick, Linda


Book ID
121348543
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
659 KB
Volume
39
Category
Article
ISSN
0022-2623

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โœ Vincent J. Kalish; John H. Tatlock; Jay F. Davies II; Stephen W. Kaldor; Bruce A ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 290 KB

The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor