ChemInform Abstract: Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure.
β Scribed by K. R. ROMINES; K. D. WATENPAUGH; W. J. HOWE; P. K. TOMICH; K. D. LOVASZ; J. K. MORRIS; M. N. JANAKIRAMAN; J. C. LYNN; M.-M. HORNG; K.-T. CHONG; R. R. HINSHAW; L. A. DOLAK
- Book ID
- 112028655
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor