ChemInform Abstract: Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation.
β Scribed by A. K. GHOSH; J. F. KINCAID; D. E. WALTERS; Y. CHEN; N. C. CHAUDHURI; W. J. THOMPSON; C. CULBERSON; P. M. D. FITZGERALD; H. Y. LEE; S. P. MCKEE; P. M. MUNSON; T. T. DUONG; P. L. DARKE; J. A. ZUGAY; W. A. SCHLEIF; M. G. AXEL; J. LIN; J. R. HUFF
- Book ID
- 112041063
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor
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