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Structure and function of γ-secretase

✍ Scribed by Alexandra Tolia; Bart De Strooper


Book ID
116881412
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
557 KB
Volume
20
Category
Article
ISSN
1084-9521

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Identity and function of γ-secretase
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## Abstract γ‐Secretase catalyzes intramembrane proteolysis of various type I membrane proteins, including the amyloid‐β precursor protein and the Notch receptor. Despite its importance in the pathogenesis of Alzheimer's disease and to normal development, this protease has eluded identification unt