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Identity and function of γ-secretase

✍ Scribed by W. Taylor Kimberly; Michael S. Wolfe

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
184 KB
Volume
74
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

γ‐Secretase catalyzes intramembrane proteolysis of various type I membrane proteins, including the amyloid‐β precursor protein and the Notch receptor. Despite its importance in the pathogenesis of Alzheimer's disease and to normal development, this protease has eluded identification until only very recently. Four membrane proteins are now known to be members of the protease complex: presenilin, nicastrin, aph‐1, and pen‐2. Recent findings suggest that these four proteins are sufficient to reconstitute the active γ‐secretase complex and that together they mediate the cell surface signaling of a variety of receptors via intramembrane proteolysis. © 2003 Wiley‐Liss, Inc.

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