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Structure and absolute configuration of the polyene macrolide antibiotic amphotericin B

✍ Scribed by W. Mechlinski; C.P. Schaffner; P. Ganis; G. Avitabile

Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
197 KB
Volume
11
Category
Article
ISSN
0040-4039

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✦ Synopsis

As a result of the x-ray single crystal analysis of N-iodoacetylamphotericin B the chemical and stereochemical absolute structure ia presented (I). A similar etructure and stereochemistry wae extended to the parent compound itself, amphotericin B, a heptaene macrolide antifungal antibiotic possessing a free amino group in the sugar moiety. The configuration of the asymmetric centers of the macrolide lactone ring based on the absolute stereochemistry of mycosamine 1,2 are given under the Cahn-Ingold-Prelog system'

in Table 1.

πŸ“œ SIMILAR VOLUMES

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