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Structure-activity relationships of α-conotoxins targeting neuronal nicotinic acetylcholine receptors

✍ Scribed by Emma L. Millard; Norelle L. Daly; David J. Craik

Book ID
110915070
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
244 KB
Volume
271
Category
Article
ISSN
1432-1327

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## Abstract α‐Conotoxins, from cone snails, and α‐neurotoxins, from snakes, are competitive inhibitors of nicotinic acetylcholine receptors (nAChRs) that have overlapping binding sites in the ACh binding pocket. These disulphide‐rich peptides are used extensively as tools to localize and pharmacolo