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αA-Conotoxin OIVA defines a new αA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors

✍ Scribed by Russell W. Teichert; Jean Rivier; John Dykert; Laura Cervini; Jozsef Gulyas; Grzegorz Bulaj; Michael Ellison; Baldomero M. Olivera

Book ID: 116921157
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 152 KB
Volume: 44
Category: Article
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2004.05.026

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## Abstract α‐Conotoxins, from cone snails, and α‐neurotoxins, from snakes, are competitive inhibitors of nicotinic acetylcholine receptors (nAChRs) that have overlapping binding sites in the ACh binding pocket. These disulphide‐rich peptides are used extensively as tools to localize and pharmacolo