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Structure-Activity Relationships of New Taxoids Derived from 14.beta.-Hydroxy-10-deacetylbaccatin III

✍ Scribed by Ojima, Iwao; Park, Young Hoon; Sun, Chung-Ming; Fenoglio, Ivana; Appendino, Giovanni; Pera, Paula; Bernacki, Ralph J.


Book ID
127373118
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
703 KB
Volume
37
Category
Article
ISSN
0022-2623

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Paclitaxel, docetaxel and a series of new analogs synthesized from 14␀-hydroxy-10-deacetylbaccatin III (14-OH-DAB), a natural diterpene closely related to the core synthon of the 2 above prototypes, were tested in vitro for their growth-inhibitory activity on different human cancer cell lines, inclu