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14?-Hydroxy-10-deacetylbaccatin III, a new taxane from Himalayan yew (Taxus wallichiana Zucc.)

โœ Scribed by Appendino, Giovanni; Gariboldi, Pierluigi; Gabetta, Bruno; Pace, Roberto; Bombardelli, Ezio; Viterbo, Davide


Book ID
111878259
Publisher
Royal Society of Chemistry
Year
1992
Weight
575 KB
Volume
21
Category
Article
ISSN
1472-7781

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Paclitaxel, docetaxel and a series of new analogs synthesized from 14โค-hydroxy-10-deacetylbaccatin III (14-OH-DAB), a natural diterpene closely related to the core synthon of the 2 above prototypes, were tested in vitro for their growth-inhibitory activity on different human cancer cell lines, inclu